Lesson plan
Pubmeth
PubMeth is a database that contains information about DNA hypermethylation in cancer. It can be queried either by searching a list of genes, or cancer (sub)types. It was created at the Laboratory for Bioinformatics and Computational Genomics in the Department of Molecular Biotechnology at Ghent University, Belgium. It was published in Nucleic Acids Research. A comparable database is MethDB. However, it is not optimized to cancer-related queries. Another database is MethPrimerDB which focuses on detection methodologies such as Methylation-specific primer design (MSP primer design). However, according the research published in the original article about PubMeth: Both databases discussed here, depend on submissions by administrators or users, which guarantees the required quality of the databases, but consequently they are not always complete and up to date. The databases are neither designed to rank and summarize cancer-related information [genes and cancer (sub)types involved], although this is crucial in applied methylation research in the cancer field.
Article summary
PubMeth is a database that contains information about DNA hypermethylation in cancer. It can be queried either by searching a list of genes, or cancer (sub)types. It was created at the Laboratory for Bioinformatics and Computational Genomics in the Department of Molecular Biotechnology at Ghent University, Belgium. It was published in Nucleic Acids Research. A comparable database is MethDB. However, it is not optimized to cancer-related queries. Another database is MethPrimerDB which focuses on detection methodologies such as Methylation-specific primer design (MSP primer design). However, according the research published in the original article about PubMeth: Both databases discussed here, depend on submissions by administrators or users, which guarantees the required quality of the databases, but consequently they are not always complete and up to date. The databases are neither designed to rank and summarize cancer-related information [genes and cancer (sub)types involved], although this is crucial in applied methylation research in the cancer field.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.