Lesson plan

Replication error phenotype

The positive replication error phenotype (RER+) defines a subgroup of tumors that have been documented well in Hereditary nonpolyposis colorectal cancer (HNPCC). More recently, this phenotype also has been described in breast carcinoma and is a predictor of metastases.

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Article summary

The positive replication error phenotype (RER+) defines a subgroup of tumors that have been documented well in Hereditary nonpolyposis colorectal cancer (HNPCC). More recently, this phenotype also has been described in breast carcinoma and is a predictor of metastases.

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

Bibliography

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Key claims and bibliography are generated from the same tracked claims and sources as the article page.