RepSox
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RepSox is a small molecule inhibitor of TGFβR1, also known as ALK5. As a mimetic of the effects of the SOX2 protein, it has gained attention in the fields of stem cell research and regenerative medicine. It was identified after the discovery of the Yamanaka factors. It has shown promise in a variety of in-vitro and in-vivo rodent trials modelling various diseases. It inhibits TGFβR1 autophosphorylation by preventing the protein from binding with ATP, inhibits the binding of TGF-β to TGFβR1, and prevents the transcription of genes activated by TGFβR1 with nanomolar potency. RepSox is a member of the 1,5-naphthyridine class.
RepSox is a small molecule inhibitor of TGFβR1, also known as ALK5. As a mimetic of the effects of the SOX2 protein, it has gained attention in the fields of stem cell research and regenerative medicine. It was identified after the discovery of the Yamanaka factors. It has shown promise in a variety of in-vitro and in-vivo rodent trials modelling various diseases. It inhibits TGFβR1 autophosphorylation by preventing the protein from binding with ATP, inhibits the binding of TGF-β to TGFβR1, and prevents the transcription of genes activated by TGFβR1 with nanomolar potency. RepSox is a member of the 1,5-naphthyridine class.
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