Lesson plan
RncO
RncO is a bacterial non-coding RNA regulatory element found in the rnc leader sequence. The rnc operon is negatively auto-regulated by transcript stability. rnc, the first gene in the operon codes for RNase III which cleaves the long rncO stem II leading to transcript degradation and a reduction in translation. Matsunaga et al. showed that RNase III cleavage can initiate rnc transcript decay independently of rnc gene translation. Further work has established that rncO structure and function is conserved in Salmonella typhimurium.
Article summary
RncO is a bacterial non-coding RNA regulatory element found in the rnc leader sequence. The rnc operon is negatively auto-regulated by transcript stability. rnc, the first gene in the operon codes for RNase III which cleaves the long rncO stem II leading to transcript degradation and a reduction in translation. Matsunaga et al. showed that RNase III cleavage can initiate rnc transcript decay independently of rnc gene translation. Further work has established that rncO structure and function is conserved in Salmonella typhimurium.
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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