Smet
≈ 3 min read
Names in other languages
- cebSmet
- NederlandsSmet
- SvenskaSmet
Article bodies are English and are not machine-translated. A name in another language is not a translation of the article.
SmeT is a transcriptional repressor protein of 24.6 kDa, found in the pathogenic bacteria Stenotrophomonas maltophilia. SmeT is responsible for the regulation of the Multidrug Resistance (MDR) efflux pump, SmeDEF, that gives the bacteria resistance to several antibiotics including macrolides, TMP/SMX, tetracycline, chloramphenicol, quinolones, and erythromycin. SmeT is encoded 223 bp upstream of SmeDEF, with just 56 base pairs between their transcription start sites and an overlapping region between the promoters. The production of the SmeT protein downregulates its own transcription, along with that of the efflux pump by sterically hindering the binding of RNA Polymerase to the DNA. SmeDEF was the first MDR pump discovered in the S. maltophilia species. The pump is named by its different parts: SmeE, the transporter itself that spans the plasma membrane, SmeF, the protein on the outer portion of the membrane, and SmeD, a membrane fusion protein. On general purpose media and no selectors, the genes for MDR pumps are typically not expressed, and the repressor is found bound to the DNA. In fact, mutations in SmeT that lead to overexpression of SmeDEF can pose fitness challenges to the bacteria. However, this overexpression has been identified in the bacterium and may pose a threat to our health.
Smet is a Dutch occupational surname. Smet is a regional form of Smid ("Smith") and is equivalent to the more abundant surname Smit. It is common in East Flanders. People named Smet include: David Smet (born 19661), French singer/songwriter and amateur sports car racer Eugenia Smet (1825–1871), French founder of the Society of Helpers of the Holy Souls Henrich Smet (1535/7-1614), Flemish court physician and humanist Kathleen Smet (born 1970), Belgian triathlete Jean-Philippe Smet (1943–2017), French singer and actor, father of David and Laura Laura Smet (born 1983), French actress Marc Smet (born 1951), Belgian long-distance runner Miet Smet (1943–2024), Belgian politician Mike Smet (born 1991), Belgian footballer Pascal Smet (born 1967), Belgian politician, Flemish government minister Tony Smet (born 1870, date of death unknown), Belgian fencer
See also
Smets, surname De Smet (surname) De Smet (disambiguation)
References
Text derived from https://en.wikipedia.org/w/index.php?oldid=1315325479 under CC BY-SA 4.0; modifications have been made.