SPDEF
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SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. Originally named PDEF (Prostate derived ETS factor, also called PSE or prostate specific ETS ), SPDEF is an ETS transcription factor expressed in prostate epithelial cells. In the gastrointestinal tract and lungs, it is expressed in mucus-secreting cells including intestinal and airway goblet cells, intestinal Paneth cells, gastric mucus gland and mucus neck cells, and Brunner's gland cells. In the prostate, SPDEF acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]
SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. Originally named PDEF (Prostate derived ETS factor, also called PSE or prostate specific ETS ), SPDEF is an ETS transcription factor expressed in prostate epithelial cells. In the gastrointestinal tract and lungs, it is expressed in mucus-secreting cells including intestinal and airway goblet cells, intestinal Paneth cells, gastric mucus gland and mucus neck cells, and Brunner's gland cells. In the prostate, SPDEF acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]
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