Lesson plan
SPRTN
Spartan (SPRTN) is a protein that in humans is encoded by the SPRTN gene. It is involved in DNA repair. Mutations in the SPRTN gene Ruijs-Aalfs syndrome is an autosomal recessive genetic disorder. Characteristics of this disorder are features of premature aging, chromosome instability and development of hepatocellular carcinoma. Ruijs-Aalfs syndrome arises as a result of mutations in the SPRTN gene that encodes a metalloproteinase employed in the repair of protein-linked DNA breaks. SPRTN stands for SprT-domain at the N terminus, and the name comes from the E. coli gene SprT (stationary phase regulated). The gene SprT was named in 1996 by Dr. Ryutaro Utsumi, whose team identified the gene while searching for regulators of the bolA1 transcriptional regulator in the stationary phase.
Article summary
Spartan (SPRTN) is a protein that in humans is encoded by the SPRTN gene. It is involved in DNA repair. Mutations in the SPRTN gene Ruijs-Aalfs syndrome is an autosomal recessive genetic disorder. Characteristics of this disorder are features of premature aging, chromosome instability and development of hepatocellular carcinoma. Ruijs-Aalfs syndrome arises as a result of mutations in the SPRTN gene that encodes a metalloproteinase employed in the repair of protein-linked DNA breaks. SPRTN stands for SprT-domain at the N terminus, and the name comes from the E. coli gene SprT (stationary phase regulated). The gene SprT was named in 1996 by Dr. Ryutaro Utsumi, whose team identified the gene while searching for regulators of the bolA1 transcriptional regulator in the stationary phase.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.