Surra

infection) in a Tunisian dog Surra (from the Marathi sūra, meaning the sound of heavy breathing through nostrils, of imitative origin) is a disease of vertebrate animals. The disease is caused by protozoan trypanosomes, specifically Trypanosoma evansi, of several species which infect the blood of the vertebrate host, causing fever, weakness, and lethargy which lead to weight loss and anemia. In some animals the disease is fatal unless treated.

infection) in a Tunisian dog Surra (from the Marathi sūra, meaning the sound of heavy breathing through nostrils, of imitative origin) is a disease of vertebrate animals. The disease is caused by protozoan trypanosomes, specifically Trypanosoma evansi, of several species which infect the blood of the vertebrate host, causing fever, weakness, and lethargy which lead to weight loss and anemia. In some animals the disease is fatal unless treated.

Morphology

Trypanosoma evansi, although monomorphic in most cases, can be pleomorphic in some strains. They are characterized by a long free flagellum with a narrow drawn out posterior. Kinetoplast and dyskinetoplastic forms appear. Kinetoplast is either terminal or subterminal.

Transmission

in the blood of an infected dog Transferred by species of Tabanus flies, Trypanosoma evansi development does not take place in the actual vector. In order for the transmission to be successful, trypanosomes need to survive in the gut of the flies and be regurgitated during subsequent feeding. Since Tabanidae are most abundant during rainy and post rainy seasons, that is when most outbreaks of surra occur. In order for the transfer of the disease from the flies to the animals, interruption of feeding habits needs to occur. This direct transmission technique involves them cutting the skin with their mouths, then lapping up the blood along with connective tissue fluid. This means a good indicator of disease would be looking at trypanosome density in capillary blood and connective tissue. After transferring the infectious organisms to the host species, the flies leave to rest and during that time transmission was successful only in some cases. Because the trypanosomes remain in the food canal of the flies for 4–8 hours depending on the species, the flies can feed off of one animal's blood more than one time, thus increasing the chance of successful transmission. Although the most common method of transferring trypanosomes to other species is through Tabanus flies, there are other insects that can also transmit this disease to livestock. These blood sucking insects are Stomoxys, Haematobia (also known as Lyperosia), and Haematopota. Other methods of transmission still being studied are the passing of T. evansi thorough iatrogenic transmission. Evidence has been seen of transmission through eating infected meat and also through vampire bats in geographical areas where they are found.

Diagnosis

Some conventional parasitological techniques (CPT), such as wet blood film, and stained blood smears are used because so far, the best identifier is looking at the blood of the potentially infected host. Other tissues can be looked at, but the gold standard is identifying trypanosomes in the blood. Before the infection becomes severe, it is difficult to catch as many times these cryptic infections are undetectable by direct microscopy. Since CPT is not very sensitive, it cannot be used as a sole method of diagnosis. The haematocrit centrifugation technique (HCT) is a much better alternative. Using HCT, trypanosomes can be detected in the blood even in field conditions. Buffy coat can be used to increase detection. Detection with this method is approx 85 trypanosomes per millilitre. Rather than using live animals as test subjects, Canada used serological tests such as complement fixation tests to detect trypanosomes, and have been very successful. Other tests used look at detecting antibodies generated by the host species against T. evansi antigens. This is done using the enzyme-linked immunosorbent assays (ELISA) method. Now polymerase chain reaction (PCR) and DNA probes are being used to detect surra in animals.

Treatment

The main methods of controlling surra has been drug chemotherapy, and chemoprophylaxis in animals.

History

In South America, surra was known by the names mal de caderas (hip illness), murrina, peste boba, derrengadera, and Panama horse disease. Mal de caderas was sometimes used for rabies as well, but most commonly refers to surra. Mal de caderas spread from Brazil to eastern Bolivia in the 1840s. Because so many horses sickened and died from surra, people in eastern Bolivia from this point on were occasionally known to ride oxen, which became known as bueyes caballos (horse oxen) or bueyes de cabalgadura (riding oxen).

Text derived from https://en.wikipedia.org/w/index.php?oldid=1369067829 under CC BY-SA 4.0; modifications have been made.