TACSTD2
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Tumor-associated calcium signal transducer 2 (Trop-2) is a protein that is encoded by the TACSTD2 gene. The protein was identified via the monoclonal antibody GA733 (giving the name GA733-1). It was separately characterized as an epithelial cell-surface antigen (EGP-1) that was later recognized as a calcium signal transducer (TACSTD2/Trop-2). This intronless gene is located at the short arm of chromosome 1 (1p32.1). It encodes a carcinoma-associated antigen that is closely related to epithelial cell adhesion molecule (EpCAM/TACSTD1). It transduces an intracellular calcium signal and acts as a cell surface receptor. It is expressed in low levels in normal epithelia but is overexpressed in the membranes of many epithelial-derived cancers, including breast (especially triple-negative breast cancer), lung, gastric, colorectal, pancreatic, and ovarian, cancers. High expression of TACSTD2 in cancer drives proliferation and is associated with worse outcomes. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Tumor-associated calcium signal transducer 2 (Trop-2) is a protein that is encoded by the TACSTD2 gene. The protein was identified via the monoclonal antibody GA733 (giving the name GA733-1). It was separately characterized as an epithelial cell-surface antigen (EGP-1) that was later recognized as a calcium signal transducer (TACSTD2/Trop-2). This intronless gene is located at the short arm of chromosome 1 (1p32.1). It encodes a carcinoma-associated antigen that is closely related to epithelial cell adhesion molecule (EpCAM/TACSTD1). It transduces an intracellular calcium signal and acts as a cell surface receptor. It is expressed in low levels in normal epithelia but is overexpressed in the membranes of many epithelial-derived cancers, including breast (especially triple-negative breast cancer), lung, gastric, colorectal, pancreatic, and ovarian, cancers. High expression of TACSTD2 in cancer drives proliferation and is associated with worse outcomes. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
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