Lesson plan

THAP4

THAP domain-containing protein 4 is a protein that in humans is encoded by the THAP4 gene. It is one of twelve known members of the thanatos-associated protein (THAP) family of proteins. Members of this family share a conserved N-terminal THAP domain as well as a conserved zinc-binding module that likely mediates DNA binding. THAP4 also has a structurally distinct C-terminal region that binds heme, which is unique among human THAP proteins. THAP4 is considered a distinctive member of the THAP protein family because its C-terminal domain is able to bind heme. It thus may be a potential signaling-responsive regulatory protein, likely sensitive to nitric oxide (NO), however its exact biological targets and regulatory roles remain to be experimentally observed.

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Article summary

THAP domain-containing protein 4 is a protein that in humans is encoded by the THAP4 gene. It is one of twelve known members of the thanatos-associated protein (THAP) family of proteins. Members of this family share a conserved N-terminal THAP domain as well as a conserved zinc-binding module that likely mediates DNA binding. THAP4 also has a structurally distinct C-terminal region that binds heme, which is unique among human THAP proteins. THAP4 is considered a distinctive member of the THAP protein family because its C-terminal domain is able to bind heme. It thus may be a potential signaling-responsive regulatory protein, likely sensitive to nitric oxide (NO), however its exact biological targets and regulatory roles remain to be experimentally observed.

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  1. Summarise the article in your own words. Which single claim would you verify first, and why?
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  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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