Lesson plan
TLX
Nuclear receptor TLX, also known as nuclear receptor subfamily 2 group E member 1 (NR2E1), is a protein that in humans is encoded by the NR2E1 gene. TLX is a member of the nuclear receptor family of intracellular transcription factors and is a homologue of the Drosophila tailless gene. TLX is part of the nuclear receptor subfamily 2 of retinoid X receptor-like proteins. However, unlike the retinoid X receptors, in typical physiologic circumstances it mostly binds to DNA by itself (as a monomer) instead of binding to another protein as a dimer. Using the type I-IV classification system, this means it's likely a type IV nuclear receptor.
Article summary
Nuclear receptor TLX, also known as nuclear receptor subfamily 2 group E member 1 (NR2E1), is a protein that in humans is encoded by the NR2E1 gene. TLX is a member of the nuclear receptor family of intracellular transcription factors and is a homologue of the Drosophila tailless gene. TLX is part of the nuclear receptor subfamily 2 of retinoid X receptor-like proteins. However, unlike the retinoid X receptors, in typical physiologic circumstances it mostly binds to DNA by itself (as a monomer) instead of binding to another protein as a dimer. Using the type I-IV classification system, this means it's likely a type IV nuclear receptor.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.