TMC8
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Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene.
Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene. ==Function== The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. ==Clinical significance== Mutations in the TMC8 gene are associated with epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. ==References== ==Further reading==
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