Lesson plan
Work-up
In chemistry, work-up refers to the series of manipulations required to isolate and purify the product(s) of a chemical reaction. The term is used colloquially to refer to these manipulations, which may include: * deactivating any unreacted reagents by quenching a reaction. * cooling the reaction mixture or adding an antisolvent to induce precipitation, and collecting or removing the solids by filtration, decantation, or centrifugation. * changing the protonation state of the products or impurities by adding an acid or base. * separating the reaction mixture into organic and aqueous layers by liquid-liquid extraction. * removal of solvents by evaporation. * purification by chromatography, distillation or recrystallization. The work-up steps required for a given chemical reaction may require one or more of these manipulations. Work-up steps are not always explicitly shown in reaction schemes. Written experimental procedures will describe work-up steps but will usually not formally refer to them as a work-up.
Article summary
In chemistry, work-up refers to the series of manipulations required to isolate and purify the product(s) of a chemical reaction. The term is used colloquially to refer to these manipulations, which may include: * deactivating any unreacted reagents by quenching a reaction. * cooling the reaction mixture or adding an antisolvent to induce precipitation, and collecting or removing the solids by filtration, decantation, or centrifugation. * changing the protonation state of the products or impurities by adding an acid or base. * separating the reaction mixture into organic and aqueous layers by liquid-liquid extraction. * removal of solvents by evaporation. * purification by chromatography, distillation or recrystallization. The work-up steps required for a given chemical reaction may require one or more of these manipulations. Work-up steps are not always explicitly shown in reaction schemes. Written experimental procedures will describe work-up steps but will usually not formally refer to them as a work-up.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.