Lesson plan

Working Formulation

The Working Formulation is a classification of non-Hodgkin lymphomas, first proposed in 1982. It has become outdated in light of modern shifts in the understanding and classification of non-Hodgkin lymphomas, leading to the rise of new systems such as the Revised American European Lymphoma classification. The Working Formulation is still in use, although it is usually applied when analyzing historical data. Low Grade *Malignant lymphoma, small lymphocytic (chronic lymphocytic leukemia) *Malignant lymphoma, follicular, predominantly small cleaved cell *Malignant lymphoma, follicular, mixed (small cleaved and large cell) Intermediate grade *Malignant lymphoma, follicular, predominantly large cell *Malignant lymphoma, diffuse, small cleaved cell *Malignant lymphoma, diffuse, mixed small and large cell *Malignant lymphoma, diffuse, large cell High grade *Malignant lymphoma, large cell, immunoblastic *Malignant lymphoma, lymphoblastic *Malignant lymphoma, small noncleaved cells (Burkitt lymphoma) Miscellaneous *Composite *Mycosis fungoides *Histiocytic *Extramedullary plasmacytoma *Unclassifiable

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Article summary

The Working Formulation is a classification of non-Hodgkin lymphomas, first proposed in 1982. It has become outdated in light of modern shifts in the understanding and classification of non-Hodgkin lymphomas, leading to the rise of new systems such as the Revised American European Lymphoma classification. The Working Formulation is still in use, although it is usually applied when analyzing historical data. Low Grade *Malignant lymphoma, small lymphocytic (chronic lymphocytic leukemia) *Malignant lymphoma, follicular, predominantly small cleaved cell *Malignant lymphoma, follicular, mixed (small cleaved and large cell) Intermediate grade *Malignant lymphoma, follicular, predominantly large cell *Malignant lymphoma, diffuse, small cleaved cell *Malignant lymphoma, diffuse, mixed small and large cell *Malignant lymphoma, diffuse, large cell High grade *Malignant lymphoma, large cell, immunoblastic *Malignant lymphoma, lymphoblastic *Malignant lymphoma, small noncleaved cells (Burkitt lymphoma) Miscellaneous *Composite *Mycosis fungoides *Histiocytic *Extramedullary plasmacytoma *Unclassifiable

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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