AS03
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AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza. A dose of AS03 adjuvant contains * 10.69 mg squalene * 11.86 mg DL-α-tocopherol (vitamin E) * 4.86 mg polysorbate 80 AS03 is a kind of oil-in-water emulsion. Squalene and vitamin E form the center of small drops of AS03 while the surfactant polysorbate 80 gather on the surface to help stabilize the emulsion. AS03 is the first oil-water-adjuvant for humans that uses vitamin E. In the 2009 influenza pandemic, vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non-adjuvanted vaccines, despite their containing lower levels of viral antigen. AS03 is
AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza. A dose of AS03 adjuvant contains 10.69 mg squalene 11.86 mg DL-α-tocopherol (vitamin E) 4.86 mg polysorbate 80 AS03 is a kind of oil-in-water emulsion. Squalene and vitamin E form the center of small drops of AS03 while the surfactant polysorbate 80 gather on the surface to help stabilize the emulsion. AS03 is the first oil-water-adjuvant for humans that uses vitamin E. In the 2009 influenza pandemic, vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non-adjuvanted vaccines, despite their containing lower levels of viral antigen. AS03 is
See also
2009 flu pandemic MF59 – another squalene-based adjuvant by Novartis AS04 – another adjuvant by GSK
References
Text derived from https://en.wikipedia.org/w/index.php?oldid=1372331821 under CC BY-SA 4.0; modifications have been made.