Lesson plan

AS03

AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza. A dose of AS03 adjuvant contains * 10.69 mg squalene * 11.86 mg DL-α-tocopherol (vitamin E) * 4.86 mg polysorbate 80 AS03 is a kind of oil-in-water emulsion. Squalene and vitamin E form the center of small drops of AS03 while the surfactant polysorbate 80 gather on the surface to help stabilize the emulsion. AS03 is the first oil-water-adjuvant for humans that uses vitamin E. In the 2009 influenza pandemic, vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non-adjuvanted vaccines, despite their containing lower levels of viral antigen. AS03 is

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Article summary

AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza. A dose of AS03 adjuvant contains * 10.69 mg squalene * 11.86 mg DL-α-tocopherol (vitamin E) * 4.86 mg polysorbate 80 AS03 is a kind of oil-in-water emulsion. Squalene and vitamin E form the center of small drops of AS03 while the surfactant polysorbate 80 gather on the surface to help stabilize the emulsion. AS03 is the first oil-water-adjuvant for humans that uses vitamin E. In the 2009 influenza pandemic, vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non-adjuvanted vaccines, despite their containing lower levels of viral antigen. AS03 is

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Discussion questions

  1. Summarise the article in your own words. Which single claim would you verify first, and why?
  2. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
  3. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

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