MARCO

Article summary

Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL). MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens and cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. MARCO expression on macrophages has been associated with tumor development and also with Alzheimer's disease, via decreased responses of cells when ligands bind to MARCO.

Key claims

1. date of birth: 1977 — source: Wikipedia · confidence 0.95
2. date of birth: 1942 — source: Wikipedia · confidence 0.95

Discussion questions

1. Summarise the article in your own words. Which single claim would you verify first, and why?
2. The record states that the date of birth is "1977". What evidence would count against this claim?
3. The record states that the date of birth is "1942". What evidence would count against this claim?
4. Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
5. If two sources disagreed about one of these facts, what would you need in order to trust one over the other?

Bibliography

1. Wikipedia https://en.wikipedia.org/w/index.php?oldid=1361168101