Pertine
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, the most well-known drug of the pertine group. The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs: * Alpertine (WIN-31665) * Milipertine (WIN-18935) * Oxypertine (WIN-18501) * Solypertine (WIN-18413) Oxypertine is known to show high affinity for the serotonin 5-HT 2 and dopamine D 2 receptors (K i = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety. The pertines were developed and initially described in the 1960s and 1970s.
, the most well-known drug of the pertine group. The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs: Alpertine (WIN-31665) Milipertine (WIN-18935) Oxypertine (WIN-18501) Solypertine (WIN-18413) Oxypertine is known to show high affinity for the serotonin 5-HT 2 and dopamine D 2 receptors (K i = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety. The pertines were developed and initially described in the 1960s and 1970s.
See also
Cyclized tryptamine 5-MeO-T-NBOMe N-Benzyltryptamine Carmoxirole B-193
References
Text derived from https://en.wikipedia.org/w/index.php?oldid=1371988290 under CC BY-SA 4.0; modifications have been made.