Lesson plan
Pertine
, the most well-known drug of the pertine group. The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs: * Alpertine (WIN-31665) * Milipertine (WIN-18935) * Oxypertine (WIN-18501) * Solypertine (WIN-18413) Oxypertine is known to show high affinity for the serotonin 5-HT 2 and dopamine D 2 receptors (K i = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety. The pertines were developed and initially described in the 1960s and 1970s.
Article summary
, the most well-known drug of the pertine group. The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs: * Alpertine (WIN-31665) * Milipertine (WIN-18935) * Oxypertine (WIN-18501) * Solypertine (WIN-18413) Oxypertine is known to show high affinity for the serotonin 5-HT 2 and dopamine D 2 receptors (K i = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety. The pertines were developed and initially described in the 1960s and 1970s.
Key claims
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
Bibliography
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Key claims and bibliography are generated from the same tracked claims and sources as the article page.