Lesson plan
STEAP3
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene. STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe 3+ ) to a soluble ferrous (Fe 2+ ) form. STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).
Article summary
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene. STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe 3+ ) to a soluble ferrous (Fe 2+ ) form. STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).
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Discussion questions
- Summarise the article in your own words. Which single claim would you verify first, and why?
- Which claim in this article is most likely to be revised as the sources update? How would you check its current status?
- If two sources disagreed about one of these facts, what would you need in order to trust one over the other?
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